Benefits of a Perioperative Exercise Program on Maturation of Dialysis Arteriovenous Fistulas

Hospices Civils de Lyon2 sites in 1 country40 target enrollmentOctober 4, 2019

ConditionsArteriovenous Fistula

InterventionsHandgrip exercise program

Overview

Phase: Not Applicable
Intervention: Handgrip exercise program
Conditions: Arteriovenous Fistula
Sponsor: Hospices Civils de Lyon
Enrollment: 40
Locations: 2
Primary Endpoint: Arteriovenous Fistula (AVF diameter)
Status: Completed
Last Updated: 3 days ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

Arteriovenous fistula (AVF) is the recommended vascular access for chronic hemodialysis, as it is associated with less mortality and better patency than arteriovenous graft (AVG) or central venous catheter (CVC).

Unfortunately, AVF suffers from a high failure rate, due, in part, to poor venous diameter.

The aim of this study is to investigate whether a perioperative handgrip training can improve the diameter of AVF in patients with chronic kidney disease (CKD) (stage IV-V).

Registry

clinicaltrials.gov

Start Date

October 4, 2019

End Date

January 26, 2026

Last Updated

3 days ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Hospices Civils de Lyon

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients older than 18 years
•with chronic kidney disease (Estimated Glomerular Filtration Rate (eGFR) \<30 milliLiter/minute (mL/min))
•with follow-up at the University Hospital of Lyon Sud
•who choose hemodialysis as renal replacement therapy

Exclusion Criteria

•contraindication for arteriovenous fistula (AVF) surgery
•refusing AVF creation
•prior vascular access
•antecedent of IV substance abuse
•active cancer
•inability to perform handgrip exercise
•physical or mental disability limiting follow-up possibility
•inclusion in an other interventional study
•no social welfare

Arms & Interventions

Exercise

Intervention: Handgrip exercise program

Control

Outcomes

Primary Outcomes

Arteriovenous Fistula (AVF diameter)

Time Frame: at 6 weeks (after surgery)

Arteriovenous Fistula diameter will be measured by Doppler ultrasound

Secondary Outcomes

Emergency hemodialysis on Arteriovenous Graft (AVG)(up to 6 weeks)
Clinical maturation rate(at 6 weeks (after surgery))
Arteriovenous Fistula (AVF) interventions(up to 6 weeks)
Echographic maturation rate(at 6 weeks (after surgery))
Arteriovenous Fistula (AVF) localization (arm or forearm)(at 6 weeks (after surgery))
Emergency hemodialysis on Central Venous Catheter (CVC)(up to 6 weeks)