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Clinical Trials/NCT04870099
NCT04870099
Completed
N/A

Leveraging Computational Social Sciences and Natural Language Processing to Optimize Engagement and Response to Low-intensity CBT for Depression and Anxiety

Indiana University1 site in 1 country141 target enrollmentOctober 17, 2020
ConditionsBibliotherapy

Overview

Phase
N/A
Intervention
Not specified
Conditions
Bibliotherapy
Sponsor
Indiana University
Enrollment
141
Locations
1
Primary Endpoint
6-week Change in Kessler 6 Psychological Distress Scale (K6)
Status
Completed
Last Updated
9 months ago

Overview

Brief Summary

Common mental disorders (CMDs) like depression and anxiety account for a large proportion of disability worldwide. Access to effective treatments like cognitive-behavioral therapy (CBT) is limited and has not reduced the public health burden of psychopathology. For patients with mild-moderate CMDs, lower-intensity treatments like guided self-help CBT (GSH-CBT) are effective and more scalable (e.g., via the internet). The advent of social media has opened avenues for dissemination of GSH-CBTs and allows for passive sensing of mood, thinking, behavior, and social networks. We propose to leverage a social media platform used by over a fifth of the United States (Twitter) as a recruitment tool to virtually screen over 150 individuals, recruit N=60 to a 5-week course of GSH-CBT, and extract social media data from individuals engaged in GSH-CBT. Sociodemographic and social media data will be used to predict engagement, outcomes, and processes in GSH-CBT.

Registry
clinicaltrials.gov
Start Date
October 17, 2020
End Date
May 21, 2022
Last Updated
9 months ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Lorenzo Lorenzo-Luaces

Assistant Professor Pyschological and Brain Sciences

Indiana University

Eligibility Criteria

Inclusion Criteria

  • At least mild distress: K6 score ≥ 6
  • Having reasonably regular access to the internet or a telephone

Exclusion Criteria

  • Suicidality: Patient Health Questionnaire-9 (PHQ9) item 9 ("thoughts that you would be better off dead, or of hurting yourself ") ≥ 2 ("more than half the days")

Outcomes

Primary Outcomes

6-week Change in Kessler 6 Psychological Distress Scale (K6)

Time Frame: Change from Baseline to Week 6

Changes in K6 from baseline to Week 6. The K6 is a measure of distress and the measure is scored on a scale of 0 - 24 where higher scores indicate higher distress (i.e., are negative). Thus, lower scores relative to baseline indicate more positive outcomes.

6-week Change in the WHO 5 Well-being Index (WHO-5)

Time Frame: Change from Baseline to Week 6

Changes in WHO-5 from baseline to Week 6. The WHO-5 is a measure of well-being and the measure is scored on a scale of 0 - 100 where higher scores indicate higher satisfaction with life (i.e., are positive). Thus, higher scores relative to baseline indicate more positive outcomes.

Secondary Outcomes

  • 6-week Change in the Emotion Regulation Scale (ERQ) - Suppression Subscale(Change from Baseline to Week 6)
  • 6-week Change in Emotion Regulation Scale (ERQ) - Reappraisal Subscale(Change from Baseline to Week 6)
  • 3-month Change in Kessler 6 Psychological Distress Scale (K6; 0 - 24)(Change from Baseline to 3 Months post-treatment)
  • 3-month Change in the WHO 5 Well-being Index (WHO-5)(Change from Baseline to 3 Months post-treatment)

Study Sites (1)

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