The Effect of Granulocyte colony-stimulating factor (GCSF) Treatment for Improvement of Sensory, Motor and Sphincter Function in Patients with Spinal cord Injury
- Conditions
- Accidentstraumatic spinal cord injury.V01 - X59
- Registration Number
- IRCT201108297441N1
- Lead Sponsor
- Brain and Spinal Injury Research Center, Tehran university of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
1.Patients must be able to give voluntary consent; 2-Age between 20 to 40 years old; 3-Time between injury and enrollment greater than 1 year; 4-No evidence of cord compression, disc herniation, cord atrophy and angulation deformity on the performed MRI; 5-no evidence of lower motor neuron injury; 6-no evidence of ossification; 7-optimized SCIM questionnaire score; 8-not using indwelling catheterization; 9-no evidence of any other systemic or psychological disorder; 10-no evidence of bedsore; 11-normal Complete Blood Count; 12- evidence of incomplete spinal cord injury according to the American Spinal Injury Association Impairment Scale. Exclusion criteria: 1-evidence of drug side effects; 2-past history of hematologic disorders in patients or patients’ first degree relatives.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sensory level score, motor score. Timepoint: before the intervention, 1st, 3rd, 6th and 12th months of study. Method of measurement: according to American Spinal Injury Association (ASIA) impairment scale.
- Secondary Outcome Measures
Name Time Method Independent life ability. Timepoint: before the intervention, 1st, 3rd, 6th and 12th months of study. Method of measurement: Spinal Cord Independence Measure III.