Breath Analysis for Evaluation of Radiation Exposure in Lung Cancer Patients Treated With Radiation
Completed
- Conditions
- Lung CancerSmall Cell Lung CancerNon-Small Cell Lung Cancer
- Registration Number
- NCT01182155
- Lead Sponsor
- Stanford University
- Brief Summary
Patients treated with radiation therapy for lung tumors can experience inflammation after treatment. This study hopes to evaluate the use of breath analysis to evaluate changes in the composition of exhaled breath in patients undergoing radiotherapy. If changes can be detected, this may ultimately serve as biomarkers for identifying patients at highest risk for radiation-induced lung injury (radiation pneumonitis).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Diagnosis of any type of lung tumor
- Medical recommendation (independent of the study) that the patient undergo thoracic radiation therapy. Radiation therapy may be either fractionated or hypofractionated (i.e. radiosurgery)
- Age >= 18 years old
- Any gender and any ethnic background will be recruited
- Capable of giving written informed consent
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Exclusion Criteria
- Inability of giving written informed consent
- Pregnancy or breast-feeding
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pre and post-radiation FeNO (fraction of exhaled nitric oxide) measurements Every 3 months for 1 year
- Secondary Outcome Measures
Name Time Method Pre and post-radiation CO (carbon monoxide), CO2 (carbon dioxide), and N2O (nitrous oxide) measurements and feasibility as the fraction of patients unable to give a breath sample. Adverse events are not expected but any that appear related to the breath 1 yr
Trial Locations
- Locations (1)
Stanford University School of Medicine
🇺🇸Stanford, California, United States