Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.

• Conditions: Bariatric Surgery; Melatonin; POSTOPERATIVE PAIN
• Interventions: Diagnostic Test: melatonin

• Registration Number: NCT03107702
• Lead Sponsor: Inonu University

Brief Summary

Bariatric surgical procedures are associated with low short-term mortality and may be associated with long-term reductions in all-cause, cardiovascular, and cancer-related mortality. This surgeries are major surgeries include risk of mortality still.

Melatonin is a hormone secreted from the pineal gland. Melatonin is an antioxidant, antinociceptive, hypnotic, anticonvulsant, neuroprotective, anxiolytic, sedative and analgesic. Melatonin is neurohormone with the profile of a novel hypnotic-anesthetic agent.

The purpose of this study is to investigate the preoperative, perioperative and postoperative melatonin levels in bariatric surgery under general anesthesia and to investigate the relationship between melatonin level and analgesia requirement.

Detailed Description

Bariatric surgical procedures are associated with low short-term mortality and may be associated with long-term reductions in all-cause, cardiovascular, and cancer-related mortality. This surgeries are major surgeries include risk of mortality still.

Melatonin is a hormone secreted from the pineal gland. Melatonin is an antioxidant, antinociceptive, hypnotic, anticonvulsant, neuroprotective, anxiolytic, sedative and analgesic. Irregularity of melatonin secretion causes a sleep irregularities, psychosis in intensive care unit and some behavioral disorder. The hypnotic, antinociceptive, and anticonvulsant properties of melatonin endow this neurohormone with the profile of a novel hypnotic-anesthetic agent.

The purpose of this study is to investigate the preoperative, perioperative and postoperative melatonin levels in bariatric surgery under general anesthesia and to investigate the relationship between melatonin level and analgesia requirement.

Study Timeline

• Study Start: 2017-03-29
• Study First Submitted: 2017-03-29
• Status Verified: 2017-04
• Study First Submitted QC: 2017-04-04
• Last Update Submitted: 2017-04-04
• Study First Posted: 2017-04-11
• Last Update Posted: 2017-04-11
• Primary Completion: 2017-06-30
• Study Completion: 2017-07-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• American Society of Anesthesiologists (ASA) 3-4 status, aged between 18-65 years who are scheduled to undergo bariatric surgery.

Exclusion Criteria

Patients with cardiovascular and pulmonary disease, those with ASA III-IV and propofol, fentanyl, remifentanil and rocuronium allergy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Melatonin and bariatric surgery	melatonin	the relationship between melatonin level and analgesia requirement.

Primary Outcome Measures

Name	Time	Method
Melatonin Level	Change from Baseline melatonin at postoperative 24 hours	Melatonin is a hormone secreted from the pineal gland. It shows a daily biorhythm. Melatonin level can be measured in the blood and in urine collected for 24 hours.

Secondary Outcome Measures

Name	Time	Method
Morphine consumption	change from postoperative up to 24 hours	Morphine is analgesic agent. It will used postoperative period

Trial Locations

Locations (1)

Inonu university; 🇹🇷 Malatya, Turkey