Dual-task Performance in Young-onset PD

Not Applicable

• Conditions: Early Onset Parkinson Disease; Early Stage Parkinson Disease
• Interventions: Other: Treadmill training; Other: Game based dual-task training

• Registration Number: NCT04033393
• Lead Sponsor: National Yang Ming Chiao Tung University

Brief Summary

This study aimed to investigate the effects of Game based dual-task training with treadmill on executive function and dual-task performance in individuals with early-onset PD and discuss the correlation between the change values of executive function and dual-task performance after training. Besides, investigate cortical activation after training.

Detailed Description

Not available

Study Timeline

• Status Verified: 2019-07
• Study First Submitted: 2019-07-24
• Study First Submitted QC: 2019-07-24
• Last Update Submitted: 2019-07-25
• Study First Posted: 2019-07-26
• Last Update Posted: 2019-07-29
• Study Start: 2019-08-01
• Primary Completion: 2022-07-31
• Study Completion: 2022-07-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Diagnosed as PD and Hoehn and Yahr stage between 1~3
• Age between 20 to 80
• Able to walk 10 m independently without an assistive device
• A score of greater than or equal to 24 on the mini-mental state examination (MMSE)
• In stable medical condition allowing participation in the testing protocol and intervention

Exclusion Criteria

• Any comorbidity or disability other than PD that would preclude gait training
• Any uncontrolled health condition for which exercise was contraindicated
• Any neurological or orthopedic disease that might interfere with the study
• Server freezing of gait, FOG questionnaire > 15

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Treadmill training group	Treadmill training	Participants in treadmill training group will do treadmill training, 3 times per week for 8 weeks
Game based dual-task training group	Game based dual-task training	Participants in dual-task training group will execute game based dual-task training with treadmill, 3 times per week for 8 weeks

Primary Outcome Measures

Name	Time	Method
Dual-task walking performance	Change from baseline at 8 weeks	To evaluate gait parameters while doing dual-task walking

Secondary Outcome Measures

Name	Time	Method
Single walking performance	Change from baseline at 8 weeks	To evaluate gait parameters while doing single walking
Verbal fluency test-Chinese version	Change from baseline at 8 weeks	To evaluate executive function
Functional near-infrared spectroscopy	Change from baseline at 8 weeks	To evaluate the changes of blood perfusion in frontal lobe
Parkinson's Disease Questionnaire 39	Change from baseline at 8 weeks	To evaluate the quality of life
Timed up and go test	Change from baseline at 8 weeks	To evaluate functional walking ability
Trail-making test	Change from baseline at 8 weeks	To evaluate executive function
Dual-task costs	Change from baseline at 8 weeks	To compare the cost between doing dual task and single task
Stroop color and word test-Chinese version	Change from baseline at 8 weeks	To evaluate executive function
Frontal lobe battery test-Chinese version	Change from baseline at 8 weeks	To evaluate executive function
Digit span test	Change from baseline at 8 weeks	To evaluate executive function