Serial Biomarker meaSurements and new echocardiographic techniques in chronic Heart Failure patients result in Tailored prediction of prognosis
Completed
- Conditions
- 10019280heart failure
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 400
Inclusion Criteria
1. Men and women, aged 18 years or older, capable of understanding and signing informed consent
2. Diagnosis of chronic heart failure, systolic and diastolic, according to the guidelines of the European Society of Cardiology (ESC)
Exclusion Criteria
1. Heart failure secondary to circulatory high output conditions
2. Scheduled for surgery or intervention for both coronary and non-coronary indication within 6 months of inclusion
3. Severe renal failure for which dialysis is needed
4. Coexistent condition with life expectancy * 1 year
5. Unlikely to appear at all scheduled follow-up visits
6. Known moderate or severe liver disease
7. COPD Gold stage IV
8. Congenital heart disease
9. Linguistic barrier
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary endpoint is the composite of cardiovascular death, cardiac<br /><br>transplantation, left ventricular assist device implantation, and<br /><br>re-hospitalization for the management of acute or worsened heart failure.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints include:<br /><br>- The individual components of the primary endpoint, i.e. cardiovascular death,<br /><br>cardiac transplantation, left ventricular assist device implantation and<br /><br>re-hospitalization for acute or worsened heart failure<br /><br>- Myocardial infarction (fatal and non-fatal), stroke (fatal and non-fatal),<br /><br>percutaneous coronary intervention (PCI) and coronary artery bypass grafting<br /><br>(CABG)<br /><br>- Cardiovascular disease (includes all of the above)<br /><br>- All-cause mortality</p><br>