In Individuals With Subjective Cognitive Decline, Age, Memory and Action Speed Scores at Baseline Predict Progression to Cognitive Impairment
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Biomarkers
- Sponsor
- Centre Hospitalier Universitaire, Amiens
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Variation of neuropsychological indicators (global congnitive score) between NCD et SCD patients
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified. The investigators objective was to examine baseline neuropsychological indicators that could discriminate between people in whom the SCD progressed to a mild or major NCD and people in whom the SCD remained stable.
The investigators retrospectively included patients consulting for SCD at a university medical center's memory center (Amiens, France) and who had undergone three or more neuropsychological assessments at least 6 months apart. The relationship between domain-specific scores and the global cognitive score (GCS, as a function of final status (stable SCD vs. progression toward a mild or major NCD)) was examined using a generalized linear mixed model.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients who had been referred to the memory center at Amiens University Medical Center (Amiens, France).
- •patients who had undergone three neuropsychological assessments at least 6 months apart, from 2005
- •patients who met the criteria for SCD.
Exclusion Criteria
- •patients who didn't meet the criteria for SCD
Outcomes
Primary Outcomes
Variation of neuropsychological indicators (global congnitive score) between NCD et SCD patients
Time Frame: one year
subjective cognitive decline (SCD) neurocognitive disorders (NCD) neuropsychological indicators could discriminate between people in whom SCD progressed to a mild or major NCD and people in whom SCD remained stable. A global cognitive score was created using all 5 tests : Alice Heim 4-I tests inductive reasoning ; Short-term verbal memory was assessed with a 20-word free-recall test; Two measures of verbal fluency were used: phonemic and semantic; Vocabulary was assessed using the Mill Hill Vocabulary test.