To see the effectiveness of a drug (dexmedetomidine) given by two methods (in vein or nose) in decreasing the rise of pulse rate and blood pressure while giving anaesthesia.
Not Applicable
- Conditions
- Health Condition 1: O- Medical and SurgicalHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2019/08/020584
- Lead Sponsor
- VMMC and Safdarjung Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Adult patients (18-65 years), of either sex, having ASA physical status I
2.Undergoing elective surgery under general anaesthesia with tracheal intubation.
Exclusion Criteria
1.Patients having any nasal pathology
2.Predicted difficult laryngoscopy/ intubation
3.Pregnancy
4.Known allergy to study medication
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy of intravenous with intranasal dexmedetomidine for attenuation of haemodynamic response to laryngoscopy and tracheal intubation with regard to heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure at various time pointsTimepoint: Haemodynamic parameters heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure), oxygen saturation (SpO2) and end tidal carbon dioxide (EtCO2) will be recorded at 1.baseline <br/ ><br>2.after nasal pre-medication (at 10 and 20 min), <br/ ><br>3. 5 and 10 min of intravenous infusion of study drug/pre-induction, <br/ ><br>4.post-induction, <br/ ><br>5. 3 min post induction <br/ ><br>6. post-intubation (at 1,3,5 and 10 min)
- Secondary Outcome Measures
Name Time Method 1. Pre-induction sedation score <br/ ><br> <br/ ><br>2. Induction dose of propofolTimepoint: 1.Sedation score (Ramsay sedation score) will be recorded at <br/ ><br>a)baseline in the pre-operative area <br/ ><br>b)before induction of anaesthesia <br/ ><br>c) at recovery. <br/ ><br> 2.Induction dose of propofol required until loss of verbal contact will be noted at the time of injecting propofol