Tokushima Night Guard for Recurrent Aphthous Stomatitis
- Conditions
- Aphthous Stomatitis
- Interventions
- Device: placebo night guardDevice: night guard
- Registration Number
- NCT02890524
- Lead Sponsor
- University of Tokushima
- Brief Summary
The investigators will investigate whether the night guard can suppress the development of recurrent aphthous stomatitis (RAS). The investigators will record the patients' oral condition for 60 days before and after intervention with the night guard made of Ethylene-Vinyl Acetate copolymer (EVA). The patients' saliva will be analyzed for measurement of inflammatory cytokines or oxidative stress.
- Detailed Description
The study involved 20 patients (8 male and 12 female) with RAS. These patients suffered from RAS at least once a month. The investigators will record their oral condition for 60 days before and after intervention with the night guard made of EVA. Their saliva will be analyzed for further studies including measurement of inflammatory cytokines or oxidative stress.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Patients suffered from recurrent aphthous stomatitis at least once a month
- People do not have a experience of recurrent aphthous stomatitis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Placebo night guard placebo night guard Placebo night guard made of EVA Night guard night guard the night guard made of EVA
- Primary Outcome Measures
Name Time Method number of developed aphthous stomatitis through study completion, an average of 1 year
- Secondary Outcome Measures
Name Time Method days until healing through study completion, an average of 1 year
Trial Locations
- Locations (2)
Tada Dental Clinic
🇯🇵Kakogawa, Hyogo, Japan
Tokushima University Hospital
🇯🇵Tokushima, Japan