Methemoglobin level for predicting organ failure in sepsis

Completed

• Conditions: SepsisOrgan Failure; Septic shock; Sepsis; Methemoglobin; Area Under Receiver Operating Curve; Organ failure; SOFA; Intensive Care

• Registration Number: TCTR20211007001
• Lead Sponsor: Faculty of Medicine Ramathibodi Hospital, Mahidol University

Brief Summary

Among 30 patients, 7 patients had worsening SOFA scores. Initial methemoglobin level has an AUROC of 0.5404 (95% confidence interval 0.2603-0.8204). Using Youden index, the determined cut-off value is 0.75%. The sensitivity of this cut-off value is 71.4% (95% confidence interval 29-96.3%) and the specificity is 52% (95% confidence interval 30.6-73.2%).

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-10-14
• Study Start: 2021-10-07
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Sepsis or septic shock according to sepsis-3 criteria
2. Had an arterial line in place

Exclusion Criteria

1. Received either nitric oxide donor drugs (e.g., isosorbide dinitrate, nitroglycerin)
2. Received drugs known to induce methemoglobinemia (e.g., sulfonamide, chloroquine) before the enrolment
3. Had do-not-resuscitate orders in the medical record

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Organ Failure 72 hours after inclusion Sequential Organ Failure Assessment (SOFA) score

Secondary Outcome Measures

Name	Time	Method
Mortality ICU discharge Death status,Organ failure 12 hours, 24 hours Sequential Organ Failure Assessment (SOFA) score,Oxygenation 12, 24, 72 hours Partial pressure of Oxygen to Fractional inspired Oxygen (P/F ratio),Respiratory support status 12, 24, 72 hours On mechanical ventilation (or not) status,Hemodynamic status 12, 24, 72 hours Vasopressor doses