Effectiveness of Candesartan and Telmisartan on Morning Hypertension in Japanese Obese Patients

Not Applicable

• Conditions: Hypertension

• Registration Number: NCT00288717
• Lead Sponsor: Saitama Medical University

Brief Summary

To investigate the effects of Candesartan and Telmisartan on the home blood pressure, glucose and lipid-metabolism in the hypertensive patients with the accumulation of visceral fat by the newly developed Tele-medicine system

Detailed Description

A randomized, comparative study of the effects of Candesartan and Telmisartan on the home blood pressure, glucose and lipid metabolism in the hypertensive patients with the accumulation of visceral fat by the central registration system

Study Timeline

• Study Start: 2006-02
• Study First Submitted: 2006-02-07
• Study First Submitted QC: 2006-02-07
• Study First Posted: 2006-02-08
• Status Verified: 2007-01
• Last Update Submitted: 2007-01-09
• Last Update Posted: 2007-01-11
• Study Completion: 2007-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Circumference at waist: male ≧85 cm, female ≧90 cm
• Hypertensive patient with untreated hypertension, and casual blood pressure of systole ≧140 mmHg, or diastole ≧90 mmHg
• Hypertensive patient with hypertension under treatment, and casual blood pressure of systole ≧130 mmHg, or diastole ≧85 mmHg

Exclusion Criteria

• Significant hypertensive patient with diastolic blood pressure ≧120 mmHg
• Malignant hypertensive patient
• Patient with a contraindication to the study drugs (hypersensitivity, significant hepatic diseases, pregnant woman)
• Patient with urinary protein (qualitative) ＋～＋＋
• Patient with familial hyperlipidemia
• Other patients judged as ineligible for the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Home blood pressure in the early morning

Secondary Outcome Measures

Name	Time	Method
Body fat percentage
Body weight
Height
BMI
Blood potassium
Total cholesterol
HDL cholesterol
LDL cholesterol
Triglyceride
Blood glucose
IRI
HbAlc*
HOMA-IR
Urinary trace albumin
Creatinine
Home blood pressure at bedtime
M/E ratio
Casual blood pressure

Trial Locations

Locations (1)

Saitama Medical School Department of Renal Medicine; 🇯🇵 Saitama City, Saitama, Japan