Effect of vitaminC and E on MCI (mild cognitive impairment )among elderly people in Esfahan , ira
Not Applicable
- Conditions
- Mild Cognitive Impairment (MCI).Mild cognitive disorder
- Registration Number
- IRCT201104186217N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 222
Inclusion Criteria
Inclusion Criteria:
a. Aged between 60-75 years old in both sexes.
b. Educational level of fifth grade and upper.
Exclusion Criteria
a. Dementia, Depression, Epilepsy, Mental retardation, History of temporary loss of consciousness more than 2 hours due to head trauma, Memory problems that interfered with daily functioning , History of brain surgery and any significant neurological disease .
b. History taking in medicine such as: neuroleptic drugs, benzodiazepine, anti-Depression, anti-epilepsy and opioids 7 days before interview by MMSE.
c. Severe CVD (cardiovascular disease), anemia , liver and kidney disorders and mal-absorption.
d. Alcohol and opium addiction, smokers .
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive Performance. Timepoint: Before intervention, after intervention and 6 months after intervention. Method of measurement: The Informant Questionnaire on cognitive decline in the elderly(IQCODE) Questionaires.;Cognitive Performance. Timepoint: Before intervention, after intervention and 6 months after intervention. Method of measurement: The mini–mental state examination(MMSE).
- Secondary Outcome Measures
Name Time Method Measurment of Malondialdehyde assay for oxidative stress status of subjects. Timepoint: Before intervention, after intervention and 6 months after intervention. Method of measurement: laboratory Methods.;Measurment of Serum total antioxidant capacity for oxidative stress status of subjects. Timepoint: Before intervention, after intervention and 6 months after intervention. Method of measurement: laboratory Methods.;Measurments of 8-hydroxy-2'-deoxyguanosine for oxidative stress status of subjects. Timepoint: Before intervention, after intervention and 6 months after intervention. Method of measurement: laboratory Methods.;Measurment of Glutathion for oxidative stress of subjects. Timepoint: Before intervention, after intervention and 6 months after intervention. Method of measurement: laboratory Methods.