Detection of Nociceptive Stimulation by Analgesia Nociception Index (ANI) During Anesthesia With Propofol or Sevoflurane and Varying Remifentanil Concentrations.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- General Anaesthesia
- Sponsor
- University Hospital Schleswig-Holstein
- Enrollment
- 50
- Locations
- 1
- Last Updated
- 13 years ago
Overview
Brief Summary
The aim of this prospective randomized study was to evaluate the ability of the new Analgesia Nociception Index ANI, derived by heart rate variability, to detect painful stimulation during either propofol or sevoflurane anesthesia and changing remifentanil concentrations.
Detailed Description
Monitoring Antinociception during general anesthesia is still a big challenge in the field and has not become clinical routine yet. Recently, for the Surgical Pleth Index SPI a benefit for the patient in terms of reduction of remifentanil use, less unwanted effects and shorter recovery from anesthesia was reported. However, there are new variables like the ANI that are developed to measure antinociception during anesthesia. In the present study the investigators want to evaluate, whether ANI detects a painful tetanic stimulus during general anesthesia using propofol or sevoflurane and different concentrations of remifentanil.
Investigators
Berthold Bein
Prof. Dr. med.
University Hospital Schleswig-Holstein
Eligibility Criteria
Inclusion Criteria
- •age between 18- 65 years,
- •ASA physical status I or II,
- •elective surgery in general anesthesia planned,
- •written informed consent
Exclusion Criteria
- •pregnancy,
- •history of cardiac arrhythmia,
- •presents of any neuromuscular or neurologic disease,
- •use of CNS-active medication or abuse of alcohol/illicit drugs -
Outcomes
Primary Outcomes
Not specified