The use of ultrasound in hand osteoarthritis

Conditions: osteoarthritis
10023213

Registration Number: NL-OMON30978

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

Men or Women with hand osteoarthritis (according to ACR criteria)
Older then 45 years
Pain score 30 or more on VAS or visual analog function subscale of 225 or more of AUSCAN

Exclusion Criteria

Concomitant rheumatic disease
Cutaneous psoriasis
Underlying disease known to cause OA
Rheumatoid factor or anti CCP antibody level above reference level
Intra articular injection of one of the hand joints with corticosteroids or oral corticosteroid use less then 1 month prior to investigation

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>All hand joints will be studied on pain, swelling and loss of function. All<br /><br>joints will be scored using ultrasound on whether signs of inflammation are<br /><br>present or not.<br /><br>Analysis of the outcome measures of ultrasound findings of all painful hand<br /><br>joints will be compared to the outcome measures of non painful hand joints.<br /><br>Correction of patient characteristics will take place.<br /><br>A subanalysis will be performed within every patient. The outcome measures of<br /><br>the most painful joint (index joint) will be compared to a non painful<br /><br>osteoarthritic joint the contralateral hand preferably in the same joint or in<br /><br>the same row.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundary study parameters will be a semi-quantative score on inflammation (0<br /><br>to 3) using ultrasound of each hand joint. This might give relevant and more<br /><br>detailed information, but reliability of outcome measures might diminish.<br /><br><br /><br>Also x-ray findings will be compared to clinical signs and ultrasound findings.</p><br>