Exploring the relevance of serum MicroRNA199 alterations between knee osteoarthritis and diarrhea-predominant irritable bowel syndrome based on the efficacy of acupoints in acupuncture treatment

Phase 1

Recruiting

• Conditions: knee osteoarthritis/diarrhea-predominant irritable bowel disease

• Registration Number: ITMCTR2100004801
• Lead Sponsor: Mianyang Hospital of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion criteria for patients with KOA:
1. Meeting the ACR diagnostic criteria for KOA;
2. Having the typical symptoms of KOA;
3. Age above 18 years, regardless of gender;
4. Voluntarily accept treatment;
5. Good compliance and willingness to cooperate with the study, with the patient signing an informed consent form.

Inclusion criteria for patients with IBS-D:
1. Those who meet the above diagnostic criteria for IBS-D Rome IV;
2. Having the typical symptoms of IBS-D;
3. Age above 18 years, regardless of gender;
4. Voluntary treatment;
5. Good compliance and willingness to cooperate with the study, with the patient signing an informed consent form;
6. Lack of morphological changes and biochemical abnormalities that could explain the symptoms;
7. Those who have not received acupuncture treatment for IBS in the last 3 months prior to entering treatment.

Exclusion Criteria

Exclusion criteria for patients with KOA:
1. Patients with concomitant non-primary osteoarthritis such as rheumatoid arthritis, bone tumours, bone tuberculosis, etc;
2. Patients following knee replacement;
3. Patients who are afraid of needles, prone to needle fainting or whose needling sites are prone to bleeding, infection, ulceration or scarring;
4. Patients with a combination of serious primary illnesses such as heart, lung, liver, kidney or other major diseases;
5. Patients with mental disorders and intellectual disabilities who are unable to cooperate;
6. Patients with bleeding tendencies, allergies, scars and other skin diseases;
7. Pregnant or lactating women, those with severe skin lesions who are otherwise unsuitable for acupuncture;
8. Those who are participating in other clinical trials.

Exclusion criteria for patients with IBS-D:
1. Those who meet the diagnostic criteria of IBS-C, IBS-M, IBS-U Rome IV;
2. Those with organic lesions of the intestinal tract or systemic diseases that affect the dynamics of the digestive tract (e.g. cholecystitis, pancreatitis, hyperthyroidism, chronic renal insufficiency);
3. Those who are afraid of needle, prone to needle fainting or those who are prone to bleeding, infection, ulceration or scarring at the site of needling;
4. Those with a history of abdominal or rectal anal surgery;
5. Those who regularly take drugs or inhibitors that affect gastrointestinal dynamics or alter intestinal function;
6. Persons with a combination of serious primary illnesses such as heart, lung, liver, kidney or other major diseases;
7. Patients with mental disorders and intellectual disabilities who are unable to cooperate;
8. Patients with bleeding tendencies, allergies, scars and other skin diseases;
9. Pregnant or lactating women, those with severe skin lesions who are otherwise unsuitable for acupuncture;
10. Those who are participating in other clinical trials, or refuse to be enrolled for observation or contain other unstable factors.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
serum microRNA199;

Secondary Outcome Measures

Name	Time	Method
visual analogue scale(VAS);Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC);the MOS item short from health survey(SF-36);IBS-SSS;