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Clinical Trials/NCT03321110
NCT03321110CompletedNot Applicable

Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes From Different Sports: Cross-sectional, Interventional, and Follow-up Studies

Chung Shan Medical University1 site in 1 country43 target enrollmentStarted: December 1, 2017Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
43
Locations
1
Primary Endpoint
malondialdehyde (MDA)

Study Overview

Brief Summary

The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day).

Detailed Description

The long-term high-amount and -intensity exercise training could cause oxidative damage, muscle impairment, inflammation and exercise fatigue to athletes easily. Such above conditions will affect the exercise performances and health of athletes. The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day). Eventually, these results of this study can provide the information for the known to improve the oxidative stress, anti-oxidation and inflammation internal to the bodies of athletes for various competitions. As a consequence, the athletic performances can be further enhanced.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Basic Science
Masking
Double (Participant, Care Provider)

Eligibility Criteria

Ages
18 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Athletes (soccer and taekwondo players)

Exclusion Criteria

  • •Antioxidant vitamins users
  • •Statins or Aspirin therapy.

Arms & Interventions

Placebo

Experimental

Placebo

Intervention: Placebo (Other)

Q10-300

Experimental

coenzyme Q10 300 mg/d.

Intervention: Coenzyme Q10 (Dietary Supplement)

Q10-150

Experimental

coenzyme Q10 150 mg/d.

Intervention: Coenzyme Q10 (Dietary Supplement)

Outcomes

Primary Outcomes

malondialdehyde (MDA)

Time Frame: 12 weeks

MDA (micromol/L) will measure by thiobarbituric acid reacting substance.

Secondary Outcomes

  • Insulin(12 weeks)
  • creatine kinase (CK)(12 weeks)
  • one-repetition maximum (1-RM)(12 weeks)
  • Antioxidant capacity(12 weeks)
  • high sensitivity C-reactive protein (hs-CRP)(12 weeks)
  • Glucose(12 weeks)
  • Lactate dehydrogenase (LDH)(12 weeks)
  • HbA1C(12 weeks)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

LJ Hwu

Principal Investigator

Chung Shan Medical University

Study Sites (1)

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