Evaluation of Plasma Angiotensin II and Angiotensin II Receptor Levels in Patients With Sepsis and Septic Shock: a Prospective Observational Study.
- Conditions
- Septic ShockSepsis
- Registration Number
- NCT04716842
- Lead Sponsor
- Inonu University
- Brief Summary
Evaluation of plasma angiotensin II and angiotensin II receptor levels in patients with sepsis and septic shock: a prospective observational study.
- Detailed Description
There is an increasing number of experimental publications investigated effects of angiotensin II and receptors on the pathogenesis and treatment of sepsis and septic shock. However, its level in humans and its relationship with the severity of the disease has not been investigated. If angiotensin II plays a role in the diagnosis and prognosis of septic shock by evaluating this relationship in our study, it may be a biomarker to be used in future diagnosis, prediction of prognosis and treatment. This will enable early recognition and treatment of this disease, which causes high mortality and cost in intensive care units, thus increasing the survival rate and reducing the cost.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 75
- intensive care unit patient
- End-stage organ failure,
- immunodeficiency, vasospastic disease, pregnancy, other shock causes (hypovolemic, cardiogenic, neurogenic) a life expectancy of less than 48 hours
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method angiotensin II receptor II 0-3 days serum angiotensin II receptor II levels
angiotensin II levels 0-3 days serum angiotensin II levels
angiotensin II receptor I 0-3 days serum angiotensin II receptor I levels
- Secondary Outcome Measures
Name Time Method procalsitonine level 0-3 days Procalsitonine level
mortality 28 days mortality rate
crp level 0-3 days crp levels
Trial Locations
- Locations (1)
Ayse Belin B OZER
🇹🇷Malatya, Turkey