Community-based Exercise Therapies for Huntington's Disease

Completed

• Conditions: Dementias and Neurodegenerative Diseases Research Network; Mental and Behavioural Disorders; Huntington's Disease

• Registration Number: ISRCTN59910670
• Lead Sponsor: Cardiff University (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04-21
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. The diagnosis of Huntington's Disease (HD), confirmed by genetic testing and neurological examination (this is a routine requirement for any of the participants enrolled in the Registry study)
2. The ability to walk independently as primary means of mobility and willing to travel to the exercise centre for the intervention
3. The capacity to give informed consent
4. A total functional capacity (TFC) score of at least 7
5. A Unified Huntington's Disease Rating Scales (UHDRS) Transcranial Magnetic Stimulation (TMS) score of at least 5
6. Have maintained a stable medical regime for 4 weeks prior to initiation of study and are able to maintain a stable regime for the course of the study
7. Either gender

Exclusion Criteria

1. Have a history of additional prior major neurological condition, such as stroke
2. Have an orthopaedic condition that independently limits mobility
3. Have cardiac precautions that would prevent the subject from completing the exercise programme or completing the full battery of outcome measures
4. Demonstrate uncontrolled psychiatric symptoms
5. Are pregnant
6. Demonstrate any contraindication to exercise

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A number of outcomes that are representative of participation restriction, activity limitation as