High Dose Vitamin D Supplementation in Chronic Spontaneous Urticaria
Phase 3
- Conditions
- Urticaria
- Interventions
- Drug: Vitamin D3 (High dose)Drug: Vitamin D3 (Low dose)
- Registration Number
- NCT02873364
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Chronic spontaneous urticaria is an inflammatory disease which is characterized with intermittent or daily urticaria. This diseases lasts for more than 6 weeks. Several recent studies have suggested a role for vitamin D in modulation of immune system and pathogenesis of chronic urticaria.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- Uriticaria or angioedema daily or more than 3 days a weeks for at least 6 weeks
Exclusion Criteria
- Physical urticaria aquired or hereditary angioedema Calcium level > 10.3 mg/dl Glomerular filtration rate <50 Sarcoidosis Primary hyperparathyroidism Granulomatous diseases Malignancies Pregnancy Lactation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Vitamin D3 (High dose) Vitamin D3 (High dose) Daily 4000 unites vitamin D + Cetirizine 10mg twice a day Vitamin D3 (Low dose) Vitamin D3 (Low dose) Daily 600 unites of vitamin D + Cetirizine 10mg twice a day
- Primary Outcome Measures
Name Time Method Urticaria symptom severity questionnaire after 1 week 1 weeks Urticaria Symptom Severity ranging from 0 to 93
- Secondary Outcome Measures
Name Time Method Urticaria symptom severity questionnaire after 6 week 6 weeks Urticaria Symptom Severity ranging from 0 to 93
Urticaria symptom severity questionnaire after 12 week 12 weeks Urticaria Symptom Severity ranging from 0 to 93
Trial Locations
- Locations (1)
Shiraz University of Medical Sciences
🇮🇷Shiraz, Fars, Iran, Islamic Republic of