Antimicrobial action of cleaning methods for dentures of hospitalized patients

Not Applicable

Terminated

• Conditions: Hospitalization; General Ward; Upper Complete Denture; C07.793.597.425

• Registration Number: RBR-7gstxs6
• Lead Sponsor: Karin Hermana Neppelenbroek

Brief Summary

All the hygiene protocols tested resulted in a significant reduction in the percentage of biofilm on the upper complete denture and in the viable microorganisms from their cultures (P less than 0.05). The comparison between protocols showed a greater reduction in the medians of log10 colony forming units per milliliter and in the percentage of prosthetic biofilm for the groups that used sodium hypochlorite, 2% chlorhexidine digluconate and microwave irradiation (650 W) regardless of the association with brushing (P less than 0.05). The factors involved with prosthetic biofilm, including diagnostic hypotheses, did not significantly interfere with the effectiveness of the protocols proposed in this study (P less than 0.05). It was concluded that a simple immersion of the removable acrylic dentures in the chemical cleaning solutions of 1% sodium hypochlorite and 2% chlorhexidine digluconate for 10 min can be a simple and low cost alternative for the effective reduction of prosthetic biofilm in hospitalized patients.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2020-12-18
• Study Start: 2022-03-25
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Terminated
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients in hospital ward; both sexes; over 18 years old; users of conventional removable upper complete; any condition of the mandibular arch; any level of consciousness; any reason for hospitalization.

Exclusion Criteria

Patients with fractured and/or relined upper complete dentures.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determine the most effective hygiene protocol for reducing the biofilm present in upper complete dentures of hospitalized patients, by determining the area of coverage of prosthetic biofilm and the count of viable microbial colonies from the finding of a significant reduction in the percentage area of biofilm visible on the internal surface of the denture and the number of viable microorganisms (CFU/mL) in non-selective culture medium.

Secondary Outcome Measures

Name	Time	Method
Secondly, the adoption of an easy, efficient, affordable, and applicable protocol in a hospital environment for the hygiene of removable acrylic dentures can result in shorter hospital stays for both the prevention of infections associated with the prosthetic biofilm and the reduction of the virulence course. of a previously installed lung disease, leading to lower hospitalization costs.