NCT03541863已完成不适用
What Comes After Fulvestrant? A Real World Multicenter Retrospective Study-Treatment After Progression of Fulvestrant Among Metastatic Breast Cancer Patients in China
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- PFS
研究概览
简要总结
What Comes After Fulvestrant? A Real World Multicenter Retrospective Study-Treatment After Progression of Fulvestrant Among Metastatic Breast Cancer Patients in China.
详细描述
There is no evidence of treatment after progression of Ful. We retrospectively evaluated HR+, HER2- MBC patients failed on Ful 500mg as first line or second line therapy from 2014 to 2017 in 6 institutions. Treatment pattern, PFS, OS and safety were analyzed to figure out the situation and efficacy of treatment after Fulvestrant.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who were treated with Fulvestrant between June 2014 to June 2017 as first line or second line therapy
- •Patients received subsequent treatment after progressing on Fulvestrant for at least one cycle (>1 month)
- •Complete medical history was available
排除标准
- •Subsequent treatment was not standard therapy (cannot be classified into endocrine therapy/ chemotherapy)
- •Medical history was incomplete
结局指标
主要结局
PFS
时间窗: 6 weeks
Progression free survival
次要结局
- OS(From date of first dose until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months)
- Number of participants with treatment-related adverse events as assessed by CTCAE v4.0(6 weeks)
研究者
研究点 (1)
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