A trial to assess the usefullness of platelet rich fibrin in preventing bile leaks following living donor liver transplant.
Not Applicable
- Conditions
- Health Condition 1: - Health Condition 2: O- Medical and SurgicalHealth Condition 3: K746- Other and unspecified cirrhosis ofliver
- Registration Number
- CTRI/2022/11/047425
- Lead Sponsor
- Amrita Institute of Medical Sciences research center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All consenting adults undergoing liver transplantation for any liver disease in the department of GI surgery and solid organ transplantation, Kochi.
Exclusion Criteria
1.Deceased donor liver transplant
2.APOLT
3.Re-transplantation
4.Paediatric transplantation
5. Poor PRF formation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the difference in bile leak rate by using PRF on biliary anastomosis.Timepoint: 3month outcome
- Secondary Outcome Measures
Name Time Method 1.To assess the differences in overall outcome by use of the PRF on biliary anastomosis, to be ascertained by the following: <br/ ><br>a.Hospital stay <br/ ><br>b.ICU stay <br/ ><br>c.Vascular complications <br/ ><br>d.Need for post-operative interventions (percutaneous/endoscopic/surgical) <br/ ><br>e.Organ space infection <br/ ><br>f.Occurrence of sepsis <br/ ><br>g.Antibiotic requirement (change from protocol/increase in duration) <br/ ><br>h.3 month mortality <br/ ><br> <br/ ><br>2.To identify predictors for bile leak. <br/ ><br>3.To assess the safety in the application of PRF for biliary anastomosis. <br/ ><br>4.To determine the optimum speed and time of centrifuge by measurement of platelet concentrate and PDGF of PRF in patients with CLD. <br/ ><br>5.To correlate haematological variables with the quality of the coagulum. <br/ ><br>Any adverse effectsTimepoint: 3month outcome