Comparing Train-of-Four Recovery in the Adductor Pollicis Versus the Adductor Digiti Minimi in Elective Surgery Patients Using EMG
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 57
- 试验地点
- 1
- 主要终点
- Difference in Measured Recovery of Train of Four at Adductor Pollicis and Adductor Digiti Minimi
研究概览
简要总结
The train-of-four (TOF) ratio is a quantitative measure used in anesthesia to assess the degree of neuromuscular blockade induced by neuromuscular blocking agents during surgical procedures. Current American Society of Anesthesiologists guidelines recommend monitoring the TOF ratio to guide the administration and reversal of NMBAs, with a target ratio of 0.9 or higher at adductor pollicis muscle indicating adequate reversal and restoration of neuromuscular function.
This proposed study aims to observe and compare the TOF ratio between two different muscles of the hand: adductor pollicis and adductor digiti minim using anesthesia monitors on both of their arms during recovery of neuromuscular function. Surgery and anesthesia will occur per standard of care.
详细描述
The study population will enroll adult patients (>18) who will receive non-depolarizing neuromuscular blocking drugs as part of a routine general anesthetic and who will have monitoring of their recovery from neuromuscular block performed using the Tetragraph (Senzime Sweden). Patients with upper limb weakness, neurological deficits, and inability to use the other arm to record the second EMG recording will be excluded.
Procedures (methods):
Adult patients undergoing general anesthesia with the use of muscle relaxants will have anesthesia monitors on both of their arms. On one arm, the study sticky pad will be placed on the forearm and over the base of the little finger. On the other arm, the standard monitor is placed on the forearm and over the base of the thumb.
To identify pre-operative patients, an EPIC report will be utilized to screen for eligible participants. Patients will be contacted via phone by a research team member the day before their procedure and enrolled. Informed consent will be formally obtained on the day of the procedure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Surgery and general anesthesia with administration of non depolarizing neuromuscular blocking drug
排除标准
- •neuromuscular disease or weakness of one of upper limbs.
- •Inability to use one of subjects arms to record neuromuscular monitor.
- •Contraindication to administration or allergy to non depolarizing neuromuscular blocking drug.
研究组 & 干预措施
Adductor Pollicis EMG
The Train of Four Ratio will be recorded at 90% as a time and as a reference point
干预措施: EMG Assessement of Recovery of Neuromuscular Function (Device)
Adductor Digiti Minimi
The Train of Four Ratio will be recorded when the adductor pollicis ratio reads 90%
干预措施: EMG Assessement of Recovery of Neuromuscular Function (Device)
结局指标
主要结局
Difference in Measured Recovery of Train of Four at Adductor Pollicis and Adductor Digiti Minimi
时间窗: All assessments are intraoperative and complete in one day
The train of four ratio at the digiti minimi will be recorded when the adductor pollicis ratio reads 90 percent
次要结局
未报告次要终点