Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes: A Novel Intervention for a High Risk Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Cardiovascular responses to stress
研究概览
简要总结
This study is investigating the effects of three different diets, including a diet with pistachios, on cardiovascular disease risk markers in people with type 2 diabetes.
详细描述
The study will last 12-16 weeks and requires 10-13 visits to the General Clinical Research Center on the University Park campus. All food and snacks will be provided for 10 weeks. At the end of each of three diet periods, participants will undergo a test of endothelial function, an oral glucose tolerance test, and a cardiovascular stress reactivity test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy, nonsmoking adults, aged 30-75 years (women must be post-menopausal)
- •Diagnosed with Type 2 diabetes
排除标准
- •Insulin, more than one blood pressure lowering medication, daily aspirin, NSAID therapy, oral steroids within the last 6 weeks, oral contraceptives, and hormone replacement therapy
- •Chronic disease such as cardiovascular disease or any complications of diabetes (retinopathy, neuropathy, etc).
- •Allergies or aversions to pistachios
- •Unwillingness to consume all foods provided and no other meals or snacks for the 10 weeks of diet intervention
结局指标
主要结局
Cardiovascular responses to stress
时间窗: End of each diet period
Insulin sensitivity and resistance
时间窗: End of each diet period
Lipids and lipoproteins
时间窗: End of each diet period
次要结局
- Vascular endothelial function(End of each diet period)
- Mood and perceived stress(End of each diet period)
研究者
Sheila G West
Associate Professor
Penn State University