Effects of High-Intensity Interval Aerobic Training on Hepatic Fat Content and Liver Stiffness in Overweight and Obese Subjects with Non-Alcoholic Fatty Liver Disease

Research affairs, Faculty of Medicine, Chulalongkorn University0 个研究点目标入组 46 人开始时间: 2022年8月17日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•1.Male and female in reproductive age
•2.Age 18-50 years old
•3.Severe steatosis : Controlled Attenuation Parameter (CAP) score more than or equal 310 dB/m
•4.Body Mass Index : BMI = 25-34.9 kg/m2
•5.Sedentary lifestyle

•1.Pregnancy or prepared to pregnancy in 6 months
•2.CAP score equal or more than 400 dB/m
•3.Alcoholic fatty liver disease (20 g. in female and 30 g. in male)
•4.Fibrosis-4 (FIB-4) index equal more than 3.25, NAFLD fibrosis score (NFS) equal or more than 0.67 or liver stiffness measurement (LSM) equal or more than 10 kPa
•5.Other liver deseases included hepatitis B virus (HBV), hepatitis C virus (HCV), autoimmune liver disease, celiac disease, genetic disorders such as Wilson's disease, and alpha-1-antitrypsin deficiency, hepatic malignancies, hepatobiliary infections, and biliary tract disease
•6.Cardiac abnormalities detected by resting EKG and during exercise stress test with 12-lead EKG such as ischemic heart disease or other abnormalities that may be affected to exercise or did not pass the exercise stress test
•7.High blood pressure during exercise stress test (more than 250/115 mmHg)
•8.Injury or pain affected to exercise training
•9.There are risks/contraindications for testing such as myocardial ischemia of at least 6 weeks, uncontrolled arrhythmia, etc.
•10.Use drugs or supplements such as vitamin E, pioglitazone and liraglutide (if used, stop more than 3 months)
•11.Diabetes mellitus with insulin injection

发起方

Research affairs, Faculty of Medicine, Chulalongkorn University