?Antidepressant effect of ketamine
Phase 2
- Conditions
- Major depressive disorder.Major depressive disorder, recurrent severe without psychotic featuresF33.2
- Registration Number
- IRCT20090801002266N8
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
Major depressive patients based on DSM 5 criteria candidate for electro convulsive therapy
Age between 18-70 years old
Informed consent form obtained
Exclusion Criteria
Drug side effects which discontinuation is necessary
Patient`s disagreement to stay in study
Deterioration of patient`s symptoms
Not to respond after 4 intervention sessions.
Drug sensitivity
Severe or active hepatic renal cardiac urological disease
Substance abuse
Previous manic or hypo manic episode
Catatonia
Secondary depression due to another medical conditions
History of psychosis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depression score in hamilton depression scale. Timepoint: Before intervention, 24 hours, one week, two weeks, three weeks, four weeks and eight weeks after begining the intervention. Method of measurement: Hamilton depression scale-17 items.
- Secondary Outcome Measures
Name Time Method Suicidal scores in beck scale for suicidal ideation. Timepoint: Before intervention, 24 hours, one week, two weeks, three weeks, four weeks and eight weeks after begining the intervention. Method of measurement: Beck scale for sicidal ideation.