Total Body Irradiation Treatments for Patients Treated at European Institute of Oncology
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Overall Survival
Study Overview
Brief Summary
Patients eligible undergoing total body irradiation as candidates for bone marrow or peripheral stem cell transplant.
Detailed Description
Total Body Irradiation (TBI) is an oncological radiotherapy technique that has been used for several decades in patients undergoing bone marrow or peripheral stem cell transplantation.
The role of TBI is:
To suppress the recipient's immune system to prevent rejection of the donor's bone marrow, whether familial or non-familial.
To eradicate residual neoplastic cells following chemotherapy treatments.
TBI is typically employed in both neoplastic and non-neoplastic disorders affecting blood cell elements (e.g., acute and chronic leukemias, aplastic anemia, lymphomas, etc.), as well as other conditions such as neuroblastoma, Ewing's tumor, and pediatric sarcomas with a poor prognosis.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients undergoing total body irradiation as candidates for bone marrow or peripheral stem cell transplantation.
- •Signed informed consent
Exclusion Criteria
- •Patients who do not undergo total body irradiation
Outcomes
Primary Outcomes
Overall Survival
Time Frame: 5 years
Number of patients death
Disease free survival
Time Frame: 5 years
Number of oncological event (local recurrence, distant metastasis, other primary tumor)
Secondary Outcomes
No secondary outcomes reported