Total Body Irradiation Treatments for Patients Treated at European Institute of Oncology
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Overall Survival
研究概览
简要总结
Patients eligible undergoing total body irradiation as candidates for bone marrow or peripheral stem cell transplant.
详细描述
Total Body Irradiation (TBI) is an oncological radiotherapy technique that has been used for several decades in patients undergoing bone marrow or peripheral stem cell transplantation.
The role of TBI is:
To suppress the recipient's immune system to prevent rejection of the donor's bone marrow, whether familial or non-familial.
To eradicate residual neoplastic cells following chemotherapy treatments.
TBI is typically employed in both neoplastic and non-neoplastic disorders affecting blood cell elements (e.g., acute and chronic leukemias, aplastic anemia, lymphomas, etc.), as well as other conditions such as neuroblastoma, Ewing's tumor, and pediatric sarcomas with a poor prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing total body irradiation as candidates for bone marrow or peripheral stem cell transplantation.
- •Signed informed consent
排除标准
- •Patients who do not undergo total body irradiation
结局指标
主要结局
Overall Survival
时间窗: 5 years
Number of patients death
Disease free survival
时间窗: 5 years
Number of oncological event (local recurrence, distant metastasis, other primary tumor)
次要结局
未报告次要终点