The inhibitory effect of human beta-defensin-3 (hBD-3) on different Candida spp. isolated from patients with Candidiasis

Not Applicable

Completed

• Conditions: To investigate the inhibitory effect and/or additive, synergistic effect of hBD- 3 with antifungal drug on clinical isolates of Candida glabrata from patients with candidiasis.

• Registration Number: TCTR20181204001
• Lead Sponsor: Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-12-04
• Study Completion: 2019-06-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

Candida glabrata clinical isolated strain from patient with candidiasis

Exclusion Criteria

patient who not candida infected

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Antifungal susceptibility 48 hours after incubate yeast with antifungal drug MIC Score using CLSI method

Secondary Outcome Measures

Name	Time	Method
hBD-3 gene and protein expression on epithelial cells after C. glabrata stimulation 24, 48 and 72 hour after incubate ELISA