Chronotype Profiling in Patients with Non-Alcoholic Fatty Liver Disease

Recruiting

Conditions: Steatotic liver disease (SLD) [K76.0, K75.8]
K76.0
K75.8
Fatty (change of) liver, not elsewhere classified
Other specified inflammatory liver diseases

Registration Number: DRKS00033642

Lead Sponsor: niversitätsklinikum Knappschaftskrankenhaus Bochum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

NAFLD patients:
1. diagnosed non-alcoholic fatty liver disease (NAFLD).
2. declaration of consent to participate in the study and privacy policy.
Liver-healthy controls:
1. exclusion of non-alcoholic fatty liver disease (NAFLD).
2. age / gender / body mass index matched to an already recruited patient.
Age match included ±2 years.
3. declaration of consent to participate in the study and privacy policy.

Exclusion Criteria

Controls and NAFLD patients:
1. age under 18 years.
2. taking medication or other current therapies that may affect sleep. sleep may be affected.
3. presence of other chronic liver disease (viral hepatitis, autoimmune hepatitis, alcoholic liver disease, cholangitis, drug-associated liver damage, etc.).
4. presence of a tumor disease.
5. moderate to severe psychopathological disorders
6. eye diseases or other conditions that do not permit light dosimetry.
7. lack of prerequisites for the performance of actigraphy (e.g. physical illnesses that are associated with a significant restriction of physical activity)
8. lack of prerequisites for keeping the required diaries.
9. pregnancy or breastfeeding.
10. traveling across time zones during the outpatient study phase.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Establish comprehensive multiparametric circadian rhythms for patients with NAFLD and healthy controls.

Secondary Outcome Measures

Name	Time	Method
Identification of differences between healthy controls and patients with NAFLD in terms of frequency and extent of disruption of circadian rhythms (chronodisruption).