Investigating the effect of topical ketoconazole in preventing fungal peritonitis in children undergoing peritoneal dialysis
Phase 2
Recruiting
- Conditions
- Child– Ketoconazole – Fungal Peritonitis – Chronic Peritoneal Dialysis..
- Registration Number
- IRCT20231111060021N1
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Children undergoing peritoneal dialysis
Absence of underlying skin diseases based on initial clinical evaluation
Not have fungal peritonitis
Informed consent
Age 6 to 18 years
Exclusion Criteria
Diffuse infection requires receiving broad_spectrum antibiotics
Having an open wound at the exit site of the catheter
Need to change the catheter
Incidence of skin sensitivity with topical ketoconazole
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluating the effectiveness of topical use of 2% ketoconazole shampoo in preventing fungal peritonitis in children with peritoneal dialysis. Timepoint: Smear and culture of peritoneal fluid for fungi and bacteria are taken from patients before shampooing and after three months and after six months. Method of measurement: Returned peritoneal fluid culture and smear.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does topical ketoconazole utilize to prevent fungal peritonitis in pediatric peritoneal dialysis patients?
How does the efficacy of topical ketoconazole compare to standard antifungal prophylaxis in children on peritoneal dialysis?
Are there specific biomarkers that can identify children at higher risk for fungal peritonitis during peritoneal dialysis?
What are the potential adverse events associated with long-term topical ketoconazole use in pediatric patients?
What combination therapies or alternative antifungal agents show promise in preventing fungal peritonitis in peritoneal dialysis?