临床试验/NCT02448459

NCT02448459已完成1 期

COmbining Oral Letrozole and Clomiphene for Ovarian Stimulation (COOL-COS) Associated With Corifollitropin Alfa: a Pilot Study

University of Sao Paulo1 个研究点分布在 1 个国家目标入组 40 人开始时间: 2015年5月最近更新: 2016年5月23日

适应症

干预措施

试验速览

阶段: 1 期
状态: 已完成
发起方: University of Sao Paulo
入组人数: 40
试验地点: 1
主要终点: Number of oocytes retrieved

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This is a pilot study evaluating the effect of a simplified low-cost (friendly) controlled ovarian stimulation using clomiphene citrate, letrozole, and Corifollitropin Alfa on the number of oocytes retrieved.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 40 Years（Adult）
性别: Female
接受健康志愿者: 否

入选标准

•Women scheduled to controlled ovarian stimulation for oocyte retrieval.
•Body mass index between 18 and 35 Kg/m
•Ultrasound scan up to the third day of a menstrual cycle with absence of a dominant and active follicle (follicle >10mm and serum estradiol ≥ 40 pg/L).
•Signing an informed consent.

排除标准

未提供

研究组 & 干预措施

COOL-COS

Experimental

All women will receive Letrozole, Clomiphene, and Corifollitropin Alfa for controlled ovarian stimulation

干预措施: COOL-COS (Drug)

结局指标

主要结局

Number of oocytes retrieved

时间窗: 20 days

次要结局

Number of embryos(25 days)
Ovarian hyperstimulation syndrome(2 months)

研究者

发起方

University of Sao Paulo

申办方类型

Other

责任方

Principal Investigator

主要研究者

Wellington P Martins, MD

Associate Professor

University of Sao Paulo

研究点 (1)

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