COmbining Oral Letrozole and Clomiphene for Ovarian Stimulation (COOL-COS) Associated With Corifollitropin Alfa: a Pilot Study
Phase 1
Completed
- Conditions
- Infertility
- Interventions
- Drug: COOL-COS
- Registration Number
- NCT02448459
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
This is a pilot study evaluating the effect of a simplified low-cost (friendly) controlled ovarian stimulation using clomiphene citrate, letrozole, and Corifollitropin Alfa on the number of oocytes retrieved.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 40
Inclusion Criteria
- Women scheduled to controlled ovarian stimulation for oocyte retrieval.
- Body mass index between 18 and 35 Kg/m2.
- Ultrasound scan up to the third day of a menstrual cycle with absence of a dominant and active follicle (follicle >10mm and serum estradiol ≥ 40 pg/L).
- Signing an informed consent.
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Exclusion Criteria
- None
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description COOL-COS COOL-COS All women will receive Letrozole, Clomiphene, and Corifollitropin Alfa for controlled ovarian stimulation
- Primary Outcome Measures
Name Time Method Number of oocytes retrieved 20 days
- Secondary Outcome Measures
Name Time Method Number of embryos 25 days Ovarian hyperstimulation syndrome 2 months
Trial Locations
- Locations (1)
Setor de Reprodução Humana - HC-FMRP-USP
🇧🇷Ribeirao Preto, SP, Brazil