Comparing the Impact of Serum GPER-1 and Oxidant/Antioxidant Levels on Retinopathy in Diabetic Patients and Healthy Individuals: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Oxidative/antioxidative stress markers (malondialdehyde [MDA])
研究概览
简要总结
Observational, comparative, cross-sectional study
详细描述
This study was conducted on G protein-mediated estrogen receptor 1 (GPER-1), which is thought to be effective in preventing the development of diabetic retinopathy (DR). There are studies proving that GPER-1 prevents neuroprotective effects and vascular pathology in many tissues. In the study, serum GPER-1 and oxidative stress biomarker levels were compared in diabetic patients and healthy control groups. GPER-1 was found to be significantly increased in diabetic patients. In addition, a positive correlation was found with oxidant markers. This may lead to new treatment models in the future.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •40 individuals were required to have Proliferative Diabetic Retinopathy (PDR);
- •40 were required to have Non-PDR;
- •40 were required to be healthy, without any systemic disease.
排除标准
- •Glaucoma,
- •Ocular trauma sequelae,
- •Pathological myopia,
- •Non-diabetic retinopathy,
- •A history of previous ocular surgery,
- •Endocrine disorders (e.g.,thyroidopathy, adrenal gland disorders, pituitary pathologies),
- •Opacities interfering with fundus examination (e.g., corneal opacity, lens opacity, vitreous cloudiness other than diabetic haemorrhage).
结局指标
主要结局
Oxidative/antioxidative stress markers (malondialdehyde [MDA])
时间窗: Baseline
Variation of oxidative/antioxidative stress markers during the development of diabetic retinopathy
Progesterone
时间窗: Baseline
Variation of progeterone during the development of diabetic retinopathy
Oxidative/antioxidative stress markers (superoxide dismutase [SOD]
时间窗: Baseline
Variation of oxidative/antioxidative stress markers during the development of diabetic retinopathy
Thyroid stimulating hormone (TSH)
时间窗: Baseline
Variation of TSH during the development of diabetic retinopathy
oestradiol
时间窗: Baseline
Variation of oestradiol during the development of diabetic retinopathy
G receptor-mediated protein-1 (GPER-1)
时间窗: Baseline
Variation of GPER-1 during the development of diabetic retinopathy
Oxidative/antioxidative stress markers (catalase [CAT])
时间窗: Baseline
Variation of oxidative/antioxidative stress markers during the development of diabetic retinopathy
次要结局
未报告次要终点
研究者
Abdullah Beyoğlu
Assist of Prof
Kahramanmaras Sutcu Imam University