Post Endodontic surgery bone healing comparison-Platelet Rich Fibrin and Bone Putty: A Randomized controlled trial

In cases of significant bony defects, regeneration of the missing periapical tissue is extremely difficult. Periapical surgery uses a variety of bone transplant and regenerative materials. Bone replacement materials should be biocompatible, noncarcinogenic and should act as a scaffold for the development of new bone and gradually resorb to make room for it. Bone putty is a biomaterial that shows promising results in bone regeneration and healing. Using this bone putty, few case reports have shown healing with the development of mature bone in large periapical lesions of endodontic origin with palatal perforations. The second-generation platelet concentrates known as platelet-rich fibrin (PRF) is a rich source of growth factors and can be used to effectively induce tissue regeneration and repair. Cone beam computed tomography (CBCT) is a 3D imaging modality that provides high resolution distortion free images of the bone and surrounding structures. ITK-SNAP is an open-source software for quantifying the healing progress. Thus, the present study aims to correlate and compare bone healing with CBCT volumetric analysis after endodontic surgery using Bone putty as compared to Platelet Rich Fibrin, in one year follow up. A total of 44 patients who meet the inclusion criteria will be enrolled for clinical trial and two different materials (Platelet Rich Fibrin and Bone Putty) will be used in the bony defects. Preoperative to one year post operative reduction in volume (mm3) will be calculated and the mean values obtained for both the groups will be statistically analyzed and evaluated for any significant difference.