An Open Labelled Active Controlled Randomized Clinical study to evaluate the efficacy of Herbal formulation in the management of Dyslipidemia

Lipids, such as cholesterol or triglycerides, are absorbed from the intestines and are carried throughout the body via lipoproteins for energy, steroid production, or bile acid formation. Major contributors to these pathways are cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, and high-density lipoprotein (HDL). An imbalance of any of these factors, either from organic or non-organic causes, can lead to Dyslipidemia. Dyslipidemia is the imbalance of lipids such as cholesterol, low-density lipoprotein cholesterol, (LDL-C), triglycerides, and high-density lipoprotein (HDL). This condition can result from diet, tobacco exposure, or genetic. it can lead to cardiovascular disease with severe complications. In the list of WHO for lifestyle disorders, cardiovascular diseases take the lives of 17.9 million people every year, 31% of all global deaths. Dyslipidemia is a disorder of lipoprotein metabolism, which can include overproduction or deficiency of lipoprotein or both. Dyslipidemia can be due to familial disorders as well. Autosomal dominant mutations cause most cases of familial hypercholesterolemia in LDL receptors, which causes an elevation in LDL-C levels. The physical exam is limited in Dyslipidemia disorders. Xanthomas are deposits of lipids on the skin and sometimes subcutaneous tissue. They are yellowish and can form into plaques, nodules, or plaques. They can present on the palmar crease, which suggests familial dysbetalipoproteinemia, eyelids, or tendons. They typically are associated with hyperlipidemia, and if seen, the patient should have screening for Dyslipidemia. Various terminologies are used for Dyslipidemia like, Rasagata Sneha-vriddhi, Raktagata**Sneha vriddhi,Medo vriddhi,Medo-roga orMedo-dosha, Ama Medo dhatu and Kapha Medo Margavarana. But none of this term completely denotes Dyslipidemia. In such conditions, Charaka has mentioned that there can be no definite standardization of nomenclature of all diseases. The abnormalities in plasma lipoproteins are major risk factor for atherosclerosis. Hypercholesterolemia is directly proportional to atherosclerosis and ischemic heart disease. High cholesterol rarely showing symptoms, usually it is detected during routine blood test. Familial hypercholesterolemia may have distinct symptoms such as deposits of excess cholesterol that collect in the skin or eye tissue. Nodules in tendons in the hands or feet or rarely streaks in the hands are some other cholesterol deposits. Xanthomatosis  are yellow coloured, painless nodular masses on the body. Xanthelasma are yellowish plaques like lesions seen on the medial aspect of upper and lower eyelids, but also seen in normal individuals. Corneal arcus are greyish ring will appear along the periphery of cornea, but also seen in normal individuals.  Baddha meda ( bounded / unmovable ) are the fat which is not mobile and is stored in the form of fat at various places ( fat deposits/ omentum / muscle in the body ). Abaddha meda ( unboundable /movable ) are the fat which is mobile and circulate in the body along with in the form of lipids ( cholesterol , triglycerides , LDL , HDL , VLDL etc ).Prevalence of high cholesterol is 25–30% in urban and 15– 20% rural subjects and epidemiological studies have established a strong correlation between Premature Coronary Artery Disease / Cardiovascular disease and serum cholesterol levels. In general studies show that for each 1mg/dl decrease in LDL cholesterol in the plasma, there is about 2 percent decrease in mortality from atherosclerotic cardiovascular diseases. Therefore, appropriate preventive measures are valuable. Atorvastatin, Rosuvastatin used for treatment of Dyslipidemia, but they have side effect like elevated Transaminases, Myalgias, Arthralgias, Dyspepsia, Bloating, GI upset, Elevated Glucose, Elevated uric acid, Elevated liver function tests. Long term statin induced type 2 DM. International lipid panel- 2015 statin intolerance. Hence it is need of the day to find Ayurvedic remedy (herbal medication) for Dyslipidemia.