A Study Promoting the Influenza Response in the Elderly
- Conditions
- The trial is aimed to improve the efficiency of the seasonal influenza vaccine. Healthy volunteers who are positive for cytomegalovirus (CMV) will be recruited and given anti-viral treatment. We hypothesise that this will reduce their viral load and thereby reduce the proportion of T cells committed to CMV. This will then facilitate the development of an optimal response against the influenza vaccine.
- Registration Number
- EUCTR2011-000092-13-GB
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion criteria will be aged 65 years or above, CMV seropositive, a T cell response of over 0.5% at randomisation, relevant HLA-type, good renal function (eGFR>50ml/min).
Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) no
F.1.2.1 Number of subjects for this age range 0
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 0
Exclusion criteria will include unable to provide consent, on medication that may alter immune function, significant chronic illness as assessed by clinical team as this could affect ability to cooperate with the trial and may alter immune competence, history of a cardiovascular event in the past 6 months, and if the GP considers inappropriate to take part.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method