EUCTR2008-001647-19-NL进行中（未招募）不适用
Treatment with synthetic adrenocoticotropic hormone (ACTH) in patients with membranous nephropathy and high risk for renal failure. A pilot study. - ACTHiMe
Radboud University Nijmegen Medical Center0 个研究点开始时间: 2008年6月4日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •-Age 18-75 years
- •-Biopsy-proven idiopathic membranous nephropathy.
- •-Nephrotic syndrome: proteinuria > 3.5 g/day and serum albumine < 30 g/l
- •-Normal or mildly impaired renal function (eGFR > 60 ml/min, eGFR by
- •MDRD formula)
- •-High risk for renal failure: beta-2-microglobulin excretion > 500 ng/min
- •-Relative contra-indication for cyclophosphamide treatment :
- •a.fertility and wish for (future) family expanding
- •b.high age ( > 60 years)
- •c.former cyclophosphamide treatment
- •d.intolerance to cyclophosphamide
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •-Clinical, biochemical or histological signs of any underlying systemic
- •-Any infectious disease (including latent tuberculosis and/or latente
- •amoebiasis)
- •-Active gastic or duodenal ulcers
- •-Pregnancy, lactation, inadequate contraceptives
- •-Clinical signs of renal vein thrombosis
- •-Astma and /or any allergic conditions or hypersensitivity reactions
- •-Allergic reaction to synthetic ACTH in the past
研究者
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