To analyze the utility of deltaPCO2 gap / AVO2 content difference ratio in the assessment of tissue hypoperfusion secondary to low cardiac output state during obtuse marginal artery distal anastomosis in off-pump coronary artery bypass grafting.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 57
- 试验地点
- 1
- 主要终点
- To calculate DeltaPCO2 gap / AVO2 content difference ratio around the time of Obtuse marginal artery distal anastomosis during off-pump coronary artery bypass grafting
研究概览
简要总结
This study has been designed as a prospective observational cohort study and 57 patients scheduled for elective off-pump CABG surgery will be included in the study. We will analyze the utility of DeltaPCO2 gap / AVO2 content difference ratio in the assessment of tissue hypoperfusion secondary to low cardiac output state during Obtuse marginal artery distal anastomosis in off-pump coronary artery bypass grafting. Our Primary objective will be to calculate DeltaPCO2 gap / AVO2 content difference ratio around the time of Obtuse marginal artery distal anastomosis during off-pump coronary artery bypass grafting. The secondary outcomes will be to calculate DeltaPCO2 gap (PaCO2 – PcvO2), to analyze its correlation with tissue ischemia and to analyze the comparability of using central venous and mixed venous partial pressure of CO2, DeltaPCO2 gap (PaCO2 – PcvO2) and DeltaPCO2 gap /C(a-cv)O2 ratio.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Written informed consent Age more than 18 years Elective off‑pump coronary artery bypass graft surgery Preoperative hemoglobin more than or equal to 10 g/dl Central venous saturation-ScvO2 more than or equal to 70% American Society of Anaesthesiology -ASA Grade 2, 3 and 4.
排除标准
- •Left ventricular ejection fraction of less than 35% Unstable angina pectoris Heart failure with New York Heart Association class III‑IV Acute myocardial infarction within the last 2 weeks Previous CABG surgery Patients with chronic obstructive pulmonary disease On-table conversion to Cardiopulmonary bypass surgery known uncorrected valvular incompetence or intracardiac shunting.
结局指标
主要结局
To calculate DeltaPCO2 gap / AVO2 content difference ratio around the time of Obtuse marginal artery distal anastomosis during off-pump coronary artery bypass grafting
时间窗: As a baseline after inserting central venous and arterial access under local anesthesia-T0 | Just prior to skin incision-T1 | Next will be 5 min after flow to LAD has been established-T2 | Subsequently 5 min after the distal anastomosis to OM and settling the heart into its normal anatomical position -T3 | The mixed venous sample at T2 and T3 will be taken by the operating surgeon, from the main pulmonary artery through a purse-string suture for safety.
次要结局
- 1. To calculate DeltaPCO2 gap PaCO2 – PcvO2, to analyze its correlation with tissue ischemia.(2. To analyze the comparability of using central venous and mixed venous partial pressure of CO2, DeltaPCO2 gap (PaCO2 – PcvO2) and DeltaPCO2 gap /C(a-cv)O2 ratio.)
研究者
Dr Shravan Gowtham v
Mahatma Gandhi medical college and research institute