Randomised clinical trial to assess the feasibility for a larger study comparing the use of three Veno-Thrombo-Embolic prophylaxis treatments in patients undergoing major abdominal surgery.

Hunter New England Local Health District0 个研究点目标入组 31 人开始时间: 2019年3月22日最近更新: 2020年9月21日

适应症

试验速览

暂无简介。

•All patients 40 years and over undergoing elective major abdominal surgery with an anticipated length of stay greater than 24 hours and able to attend a 30-day follow-up bilateral lower leg venous ultrasound.

•Patients from the above group will be excluded if they have:
•Unable to give written informed consent to take part in the study,
•Active, clinically significant bleeding
•Documented congenital or acquired bleeding tendency/disorders
•Recent intracranial hemorrhage or recent (less than 3 months prior to randomization) brain spinal, or ophthalmologic surgery
•Patients where epidural or spinal anesthesia is planned and undertaken.
•Known cerebral metastasis
•Participants in whom haemostasis had not been established 6 hours after surgical closure
•Current thrombocytopenia eg platelets <70
•Renal Impairment GFR <30 and or Creatinine level above 2.0 mg/dL (180 µmol/L) in a well-hydrated participants
•Pregnant and breastfeeding women
•Participant with evidence of leg ischemia caused by peripheral vascular disease, unable to wear IPCD and graduated compression stockings.
•Participants life expectancy < 6 months,
•Clinical sign of VTE and/or history of recent VTE
•Participants who have pre-existing indication for heparins (including LMWH)

发起方