Effectiveness of Internet-based Depression Treatment

Not Applicable

Completed

• Conditions: Mild to Moderate Depressive Symptoms
• Interventions: Behavioral: Deprexis

• Registration Number: NCT01636752
• Lead Sponsor: University of Luebeck

Brief Summary

Care for people suffering from depressive symptoms should be given in a step-wise approach. One first step can be the provision of self-help material. Online self-help is an innovative way of providing self-help. The investigators want to study the effect of an interactive online self-help-program (Deprexis) in the treatment of mild to moderate depressive symptoms. Participants will be randomised to either twelve weeks of online-self help or a waiting-list control. Symptoms of depression and other aspects will be assessed over a one year period. Thereafter the controls will also receive online-self help. The investigators hypothesise that online self-help is superior to the control condition in alleviating depressive symptoms and preventing full blown depression.

Detailed Description

This study is supported by the German Ministry of Health (BMG) and is a collaborative project of Universität Bern (PD Dr. Thomas Berger), Charité Berlin (PD Dr. Matthias Rose), Universität Bielefeld (Prof. Dr. Wolfgang Greiner), Universität Hamburg (Prof. Dr. Steffen Moritz, Prof. Dr. Bernd Löwe), GAIA AG Hamburg (Dr. Björn Meyer), Universität Tübingen (Prof. Dr. Martin Hautzinger) and Universität Trier (Prof. Dr. Wolfgang Lutz).

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2012-07-05
• Study First Submitted QC: 2012-07-05
• Study First Posted: 2012-07-10
• Primary Completion: 2015-02
• Study Completion: 2017-02
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-09
• Last Update Posted: 2018-10-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1013

Inclusion Criteria

• PHQ>4 and <15

Exclusion Criteria

• acute suicidality
• psychotic d/o, bipolar d/o or other severe psychiatric d/o

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Deprexis	Deprexis	Online self-help with and without e-mail-support

Primary Outcome Measures

Name	Time	Method
Personal Health Questionnaire (PHQ-9)	12 wks

Secondary Outcome Measures

Name	Time	Method
Hamilton Rating Scale for Depression (HRSD)	12 wks, 6 mths, 12 mths
Quick Inventory of Depressive Symptoms (QIDS)	12 wks, 6 mths, 12 mths
Personal Health Questionnaire (PHQ-9)	6 mths, 12 mths

Trial Locations

Locations (4)

Charité Berlin; 🇩🇪 Berlin, Germany

Universität Bielefeld; 🇩🇪 Bielefeld, Germany

Universität Hamburg; 🇩🇪 Hamburg, Germany

Universität Lübeck; 🇩🇪 Lübeck, Germany