Detection of liver dysfunction and coagulation failure in severely burned patients using non-invasive monitoring (LiMON®, FA Getinge)

Conditions: K72.0
Acute and subacute hepatic failure
T29-T32
Burns and corrosions of multiple and unspecified body regions

Registration Number: DRKS00027883

Lead Sponsor: Klinik für Anästhesiologie, Intensiv- und Schmerzmedizin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 40

Inclusion Criteria

– mindestens eine operative Versorgung im stationären Verlauf
– Alter > 18 Jahre
– Erstversorgung in Allgemeinanästhesie unter kontrollierter Beatmung
202 / 5 000
Fordítási találatok
– Burn > 30% body surface, grade II-IV
– at least one surgical treatment during the inpatient course
– Age > 18 years
– First aid in general anesthesia with controlled ventilation

Exclusion Criteria

– pregnancy
– Age < 18 years
– Refusal to participate in the study by patients or carers or survivors
– TEN/Lyell syndrome
– Primary palliative therapy concept

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The aim of the study is to investigate the correlation of ICG-PDR, classic laboratory diagnostic markers of liver synthesis and parameters of hemostasis<br>The data collected during the course of treatment with the LiMON should be compared with the classic markers of liver function or<br>damage (transaminases, cholestasis parameters, cholinesterase, total protein, etc.) that occur in the routine course of treatment. In addition, it is planned to change the previous diagnostic routine processes<br>to systematically supplement a more intensive recording of haemostaseological changes and to correlate them with<br>the ICG-PDR and with the classical laboratory chemistry. The hemostasis characterization should at least include: aPTT, INR, D-dimer, fibrinogen, antithrombin, factor XIII, protein C, protein S, factors II, V, VII, VIII, IX,<br>X and thromboelastometry (ROTEM®)<br>Based on the above investigations, a relation to the clinical course of the burn injury is to be analysed.

Secondary Outcome Measures