ISRCTN89207035已完成未知
A placebo-controlled trial to evaluate two locally delivered antibiotic-containing (piperacillin and tazobactam verus doxycycline) gels in stage III-IV periodontitis patients
MegaGen Dental Implant Romania0 个研究点目标入组 100 人开始时间: 2022年10月21日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 100
研究概览
简要总结
2023 Results article in https://pubmed.ncbi.nlm.nih.gov/36837504/ (added 20/04/2023)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. All subjects were diagnosed with periodontitis stage III and IV
- •2. All participants fulfilled the following inclusion criteria:
- •2.1. Aged between 25 and 80 years old
- •2.2. At least 8 sites with PD = 5 mm and showing bleeding on probing
- •2.3. Clinical attachment loss =3 mm
- •2.4. Patients who have not undergone periodontal therapy in the last 12 months
排除标准
- •Patients with the following conditions were excluded:
- •1. Clinically relevant psychiatric disorders
- •2. Alcohol consumption
- •3. Autoimmune disorders
- •4. HIV infection
- •5. Untreated diabetes mellitus
- •6. Pregnancy or breastfeeding
- •7. Patients who have received periodontal therapy in the last 12 months
- •8. Patients who reported local and/or systemic antibiotic therapy within the 3 months before the baseline examination of the study
- •9. Candidiasis
- •10. Allergies to piperacillin, tazobactam, doxycycline, or to any tetracycline or penicillin or to any excipient of the products used
- •11. Systemic medication that can influence the clinical features of periodontitis
- •12. Patients who have rinsed or irrigated with antiseptics less than a month before the initial examination
- •12. Conditions that require antibiotic protection
研究者
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