ISRCTN89207035
Completed
未知
A placebo-controlled trial to evaluate two locally delivered antibiotic-containing (piperacillin and tazobactam verus doxycycline) gels in stage III-IV periodontitis patients
MegaGen Dental Implant Romania0 sites100 target enrollmentOctober 21, 2022
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Topical antibiotic gels applied adjunctively to subgingival instrumentation in stage III-IV periodontitis patients.
- Sponsor
- MegaGen Dental Implant Romania
- Enrollment
- 100
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
2023 Results article in https://pubmed.ncbi.nlm.nih.gov/36837504/ (added 20/04/2023)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. All subjects were diagnosed with periodontitis stage III and IV
- •2\. All participants fulfilled the following inclusion criteria:
- •2\.1\. Aged between 25 and 80 years old
- •2\.2\. At least 8 sites with PD \= 5 mm and showing bleeding on probing
- •2\.3\. Clinical attachment loss \=3 mm
- •2\.4\. Patients who have not undergone periodontal therapy in the last 12 months
Exclusion Criteria
- •Patients with the following conditions were excluded:
- •1\. Clinically relevant psychiatric disorders
- •2\. Alcohol consumption
- •3\. Autoimmune disorders
- •4\. HIV infection
- •5\. Untreated diabetes mellitus
- •6\. Pregnancy or breastfeeding
- •7\. Patients who have received periodontal therapy in the last 12 months
- •8\. Patients who reported local and/or systemic antibiotic therapy within the 3 months before the baseline examination of the study
- •9\. Candidiasis
Outcomes
Primary Outcomes
Not specified
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