Compare PPV With and Without Silicone Oil in Managing Postoperative Endophthalmitis

Not Applicable

Completed

• Conditions: Endophthalmitis Following Cataract Surgery

• Registration Number: NCT06990607
• Lead Sponsor: Benha University

Brief Summary

Comparing PPV with and without silicone oil in managing postoperative endophthalmitis

Detailed Description

The objective of this study is to compare the outcomes of PPV with silicone oil tamponade to PPV alone in patients with postoperative endophthalmitis by assessing visual acuity, and postoperative complications such as rhegmatogenous retinal detachment (RRD).

Study Timeline

• Study Start: 2024-01-20
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-01
• Status Verified: 2025-05
• Study First Submitted: 2025-05-17
• Study First Submitted QC: 2025-05-17
• Last Update Submitted: 2025-05-17
• Study First Posted: 2025-05-25
• Last Update Posted: 2025-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• adult patients (≥ 18 years) presenting with clinical manifestations of endophthalmitis after cataract surgery

Exclusion Criteria

• patients with concurrent ocular or systemic conditions that could potentially confound study outcomes, such as active retinal diseases unrelated to endophthalmitis
• pre-existing poor visual prognosis due to conditions like advanced glaucoma or macular degeneration, or prior ocular surgery affecting the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
visual acuity, with best-corrected visual acuity (BCVA) recorded using LogMAR	1, 2, 4, and 12 weeks postoperatively	log-MAR value (log of the minimum angle of resolution). Normal visual acuity for most adults is approximately -0.1 on this scale, which is equivalent to 20/16 on a Snellen visual acuity chart.

Trial Locations

Locations (1)

Al-Azhar University; 🇪🇬 Cairo, Egypt