Role of IL 12 and IL 23 as Potential Biomarkers in Diagnosis of Early Crohn's Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Tanta University
- Enrollment
- 110
- Locations
- 1
- Primary Endpoint
- Sensitivity of IL-23 to predict Crohn's disease
Study Overview
Brief Summary
This study aims to evaluate the role of Interleukin (IL)-12 and IL-23 as potential biomarkers in the diagnosis of early Crohn's disease.
Detailed Description
Crohn's disease (CD) is characterized by periods of remission and relapse, with symptoms ranging from abdominal pain and diarrhea to severe complications such as fistulas and intestinal obstruction.
Interleukins (ILs) are known clusters of cytokines that regulate the proliferation, development, and activation of immune cells. IL-12 is predominantly a pro-inflammatory cytokine secreted by antigen-presenting cells (APC) in response to sensing of microbial components by Toll-like receptors. Another member of this family, IL-23 is also produced by DCs and macrophages after toll-like receptors (TLRs) engagement.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age from 18 to 65 years.
- •Both sexes.
- •Patients who are suspected of having Crohn's disease clinically and by colonoscopy (like ulcers, fistulas, or skip lesions).
- •Non-specific ileitis by histopathology.
Exclusion Criteria
- •Patients with no pathological samples through colonoscopy.
- •History of other significant gastrointestinal diseases (e.g., colon cancer, ischemic bowel disease).
- •Immunosuppressive therapy or biologic agents at the time of study.
- •Previous abdominal surgeries.
Outcomes
Primary Outcomes
Sensitivity of IL-23 to predict Crohn's disease
Time Frame: 6 months after procedure
Sensitivity of IL-23 to predict Crohn's disease will be recorded.
Secondary Outcomes
- Sensitivity of IL-12 to predict Crohn's disease(6 months after procedure)
Investigators
Mohamed Galal Flefel
Lecturer of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University