NCT00857298已完成不适用
Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Effect of weight loss on body composition
研究概览
简要总结
Obese HIV-positive women with Metabolic Syndrome (HIV-MS) and obese HIV-negative women with Metabolic Syndrome will be studied before and after achieving moderate (6%-8%) diet-induced weight loss. The investigators hypothesize that health markers will improve in both groups but that the improvement will be blunted in the women with HIV-MS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Sedentary
- •Have either dyslipidemia (HDL < 50 or triglycerides > 150), waist circumference > 88cm, and impaired glucose tolerance or homeostasis model assessment value of > 3
- •Subjects with HIV-MS must have been receiving HAART for > 6 months
排除标准
- •Medication changes in the last 3 months
- •Diabetes mellitus
- •Medical problems that in the opinion of the principal investigator may interfere with patient safety
- •Substance abuse
研究组 & 干预措施
HIV-MS
Active Comparator
HIV-positive obese women with metabolic syndrome will be studied before and after losing 6-8% of body weight
干预措施: Dietary Intervention (Behavioral)
MS only
Active Comparator
HIV-negative obese women with metabolic syndrome will be studied before and after losing 6-8% of body weight
干预措施: Dietary Intervention (Behavioral)
结局指标
主要结局
Effect of weight loss on body composition
时间窗: three months
Effect of weight loss on insulin action
时间窗: three months
次要结局
- Effect of weight loss on body fat mass(three months)
- Effect of weight loss on adipose tissue distribution(three months)
- Effect of weight loss intrahepatic triglyceride content(three months)
- Effect of weight loss on insulin action adipose tissue(three months)
- Effect of weight loss on insulin action in liver(three months)
- Effect of weight loss on insulin action in skeletal muscle(three months)
研究者
研究点 (1)
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