Patterns of systemic arterial calcification in patients with chronic critical limb ischemia and its relationship to the ankle-brachial index and survival
Recruiting
- Conditions
- 10003216atherosclerosis
- Registration Number
- NL-OMON54634
- Lead Sponsor
- HagaZiekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 64
Inclusion Criteria
patients with critical limb ischemia of lower extremities (Rutherford score of
4, 5 and 6)
Exclusion Criteria
if the patient is unable to give consent.
Patients with allergy for intravenous contrast.
patients with an eGFR under 20 will be excluded from this study.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Our hypothesis is that there are two groups of patients. One, with low ankle<br /><br>brachial index and one with high ankle brachial index or incompressible<br /><br>vessels. In the group with the low ABI we expect atheroclesoriss (intimal<br /><br>disease) to be the main cause. We expect in this group intimal calcifications<br /><br>to be found in all vascular territories.<br /><br>In the group with the high ABI we expect arteriosclerosis and atherosclerosis<br /><br>in all territories. We hypothesized by identifying those two groups, we can<br /><br>stratify high risk patients. Furthermore, we expect that the ABI is related to<br /><br>the degree of calcification. </p><br>
- Secondary Outcome Measures
Name Time Method <p>nvt</p><br>