A study and intervention method for factors affecting weight change after curative gastrectomy for the patients of the gastric cancer
- Conditions
- Neoplasms
- Registration Number
- KCT0007567
- Brief Summary
Background: Weight changes after gastrectomy affect not only quality of life but also prognosis and survival. However, it remains challenging to predict the weight changes of individual patients. Using clinicopathological variables, we built a user-friendly tool to predict weight change after curative gastrectomy for gastric cancer. Materials and Methods: The clinical data of 984 patients who underwent curative gastrectomy between 2009 and 2013 were retrospectively reviewed and analyzed. Multivariate logistic regression was performed to identify variables predictive of postoperative weight change. A nomogram was developed and verified via bootstrap resampling. Results: Age, sex, performance status, body mass index, extent of resection, pathological stage, and postoperative weight change significantly influenced postoperative weight recovery. Postoperative levels of hemoglobin, albumin, and ferritin, and total iron-binding capacity were significant covariates. The nomogram performed well (concordance index = 0.637); calibration curves indicated appropriate levels of agreement. We developed an online version of the weight prediction tool based on the nomogram (http://gc-weightchange.com/en/front/). Conclusion: The novel, Web-based predictive nomogram allows surgeons to explore patient weight patterns quickly. The model identifies patients at high risk for weight loss after gastrectomy; such patients require multidisciplinary medical support.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 984
The inclusion criteria were primary gastric cancer, no other malignancy, no preoperative chemotherapy, no distant metastasis, R0 resection (no residual macroscopic or microscopic tumor), regular outpatient follow-up without disease recurrence for more than 5 years, and no missing values.
Patients were excluded if their postoperative weights were not recorded, or if they were lost to follow-up or died within 5 years after surgery.
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Factors affecting weight loss and weight gain in patients after curative gastrectomy
- Secondary Outcome Measures
Name Time Method Identify the factors affecting the weight change of patients after gastric cancer surgery, and identify the interventional factors that can be implemented to correct the excessive weight change