Vascular Function on the First Day After Cardiac Surgery

Completed

• Conditions: Coronary Artery Disease

• Registration Number: NCT02001090
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique. Increased flow is achieved trough obstructing blood flow with a cuff around the forearm for five minutes. FMD is measured before surgery and on the first morning after the operation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-11-27
• Study First Submitted QC: 2013-11-27
• Study Start: 2013-12
• Study First Posted: 2013-12-04
• Primary Completion: 2014-04-29
• Study Completion: 2014-04-29
• Status Verified: 2017-09
• Last Update Submitted: 2017-09-18
• Last Update Posted: 2017-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• admitted for coronary artery bypass surgery

Exclusion Criteria

• Ongoing treatment with nitrates or RAAS inhibiting drugs
• unstable coronary syndrome
• unstable circulation/shock
• renal failure
• hepatic failure
• autoimmune or inflammatory disease
• untreated hypertension.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
flow mediated dilation of the brachial artery	one day	Transitory change in FMD as a consequence of cardiac surgery with use of extra corporal circulation.

Secondary Outcome Measures

Name	Time	Method
Reactive hyperemia	one day	Transitory change in reactive hyperemia after five minutes of occlusion of forearm blood flow as a consequence of cardiac surgery with the use of extra corporal circulation.

Trial Locations

Locations (1)

St. Olavs Hospital; 🇳🇴 Trondheim, Sør Trøndelag, Norway