Microcirculation in Spontaneous Breathing Trial

Completed

• Conditions: Critically Ill
• Interventions: Other: Microcirculation examination

• Registration Number: NCT04711590
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients. Weaning parameters and spontaneous breathing trial are used to investigate the indication and predict the successful extubation. Hemodynamic stability and physical reserve are important indicators as well. Microcirculation parameters are known to be more sensitive to the change of hemodynamic status than macrocirculation parameters. We hypothesize that the change of sublingual microcirculation before and after spontaneous breathing trial is different between the the patients with successful extubation and the patients with failed extubation. Thus, this study measures sublingual microcirculation in patients receiving spontaneous breathing trial and record the extubation status (successful or failed). The microcirculation parameters before and after spontaneous breathing trial are compared between the the patients with successful extubation and the patients with failed extubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-12-05
• Study First Submitted: 2021-01-13
• Study First Submitted QC: 2021-01-14
• Study First Posted: 2021-01-15
• Status Verified: 2022-04
• Primary Completion: 2022-06-13
• Study Completion: 2022-09-30
• Last Update Submitted: 2022-12-12
• Last Update Posted: 2022-12-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

• critically ill patients received ventilator longer than 12 hours
• ready for spontaneous breathing trial
• GCS coma score equal or higher than 8

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Exclusion Criteria

• aged less than 20 years
• patient with tracheostomy
• patient and patients' relatives are non-native speakers

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Failed extubation	Microcirculation examination	The patients pass the spontaneous breathing trial and are successful extubated with reintubation within 72 hours. .
Successful extubation	Microcirculation examination	The patients pass the spontaneous breathing trial and are successful extubated without reintubation within 72 hours. .

Primary Outcome Measures

Name	Time	Method
Initial total vessel density	0 hour	Total vessel density measured by Cytocam before and after spontaneous breathing trial
Change of total vessel density	baseline and 1 hour	The difference between the total vessel density measure by Cytocam before and after spontaneous breathing trial

Secondary Outcome Measures

Name	Time	Method
Initial perfused vessel density	0 hour	Perfused vessel density measured by Cytocam before spontaneous breathing trial
Change of perfused vessel density	baseline and 1 hour	The difference between the perfused vessel density measure by Cytocam before and after spontaneous breathing trial

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan